Health Institute Carlos III

The Karolinska Institute has awarded the Nobel Prize in Medicine or Physiology to Katalin Karikó and Drew Weissman for their groundbreaking discoveries, which have radically changed our understanding of how mRNA interacts with our immune system, and made it possible to develop vaccines at unprecedented speed during the covid-19 pandemic.

On the eve of an episode of unusually high temperatures for this time of year, it is time to take stock of the summer we have experienced, characterised by a succession of extreme weather phenomena in the form of heat waves, drought and torrential rains. The seriousness and complexity of these problems and their repercussions in many areas, especially on health, make it urgent to set up the Health and Climate Change Observatory approved last July, with a stable and independent structure.

Chronic exposure to various air pollutants has been linked to an increased risk of stroke, but the short-term effects have been less well studied. A review of 110 papers and more than 18 million stroke cases shows that recent exposure - in the five days prior to stroke - also increases the likelihood of stroke. The results are published in the journal Neurology.

Counting deaths attributable to the effects of high temperatures is basic as a public health surveillance tool, but it should not become the only research objective. It is necessary to know why the population in some places adapts better than others to heat waves, what variables influence them, and to modify them when possible.

Living near green spaces over a long period of time is associated with better health, an association more marked in women and white people than in men and black people, according to a study conducted in four US cities. The analysis concludes that exposure to urban green space between 1985 and 2006 is associated with slower epigenetic ageing, and that this association is stronger in disadvantaged neighbourhoods. The international team publishing this paper in Science Advances includes a researcher from ISGlobal in Barcelona. 

Although outbreaks of H5N1 avian influenza have reached record numbers in recent years, human infections remain anecdotal. A study published today in Nature identifies a protein responsible for inhibiting the replication of this virus in humans, while 'human' flus are able to evade it. The authors propose that this protein with antiviral activity evolved in primates and consider that resistance or sensitivity to it should be taken into account when assessing the zoonotic potential of avian influenza viruses.

On 5 April, the UK National IHR Focal Point informed WHO of an increase in severe myocarditis in neonates associated with enterovirus infection in Wales (UK). Between June 2022 and April 2023, ten hospitalised neonates with a positive PCR for enterovirus were found to have myocarditis. Seven of the ten cases were confirmed to have coxsackievirus B3 or coxsackievirus B4. As of 5 May 2023, one patient remained hospitalised and one patient had died. According to the WHO statement, although enterovirus infections are common in neonates and infants, the reported increase in myocarditis - inflammation of heart muscle tissue - with severe outcome associated with enterovirus infection is unusual.

A drug in gel form cured 100 percent of mice with a very aggressive brain tumor. The authors hope that this is a first step towards helping human patients with glioblastoma, one of the most dangerous brain tumors in humans. The article is published today in PNAS.

A study published in the journal Science Translational Medicine shows the results of a phase 1 trial of a new broad-spectrum influenza vaccine. Prepared in the form of nanoparticles containing the H1 hemagglutinin stem-a region that is often conserved in different subtypes of the virus-the vaccine was generally well tolerated by participants, who showed only mild side effects such as tenderness and headaches. The prototype generated an antibody response to group 1 influenza viruses in all age groups.

Between 10-15% of childhood brain tumours are diffuse midline gliomas, a type of tumour that occurs within the brainstem, making it almost impossible to remove surgically. Research published in Science Translational Medicine has used a type of molecule (antisense-ASO oligonucleotides) in mouse models of this tumour to slow tumour growth and prolong survival. The authors hope that the research will reach clinical trials and, in that case, the potential new treatment would be combined with others such as radiotherapy or immunotherapy with CAR-T cells.