Health Institute Carlos III

A team in China has transplanted a pig lung, genetically modified using CRISPR, into a brain-dead human. According to the researchers, this is the first time a lung transplant of this kind has been performed. The organ remained viable for the nine days of the study, although it showed some signs of damage and immune rejection. The results are published in the journal Nature Medicine.

The Pan American Health Organisation has maintained its epidemiological alert for Oropouche fever since it was first issued in February 2024. Although the virus only circulates endemically in the Americas, the importation of cases to Europe following international travel is keeping health agencies and authorities on alert.

In the US, the incidence of colorectal cancer increased in people aged 45-49 years in the period 2019-2022, after advancing the screening age from 50 to 45 years, according to a study published in JAMA. The use of mailed faecal tests made it possible to reach people in this age group, without affecting screening rates in people over 50, says another paper published in the same journal.

In 2015, the United Kingdom became the first country to pass legislation allowing the use of mitochondrial donation technology, pronuclear transfer. The technique is designed to limit, through in vitro fertilization, the transmission of mitochondrial DNA diseases in babies born to women who are at high risk, and for which there is no cure. Two studies published in the New England Journal of Medicine (NEJM) describe the results of the first treatments performed to date, from which eight babies have been born by mitochondrial donation, with reduced risk of disease.

An international team has analysed data from more than 160,000 people in 40 different countries, including Spain, to study differences in the speed of ageing between regions and the factors responsible. According to the results, European countries show healthier ageing, while low-income countries are associated with accelerated ageing. Protective factors include physical factors such as air quality; social factors such as socioeconomic and gender equality; and sociopolitical factors such as freedom of political parties and democratic elections. The study is published in the journal Nature Medicine.

The State Meteorological Agency (AEMET) has reported that a warm weather will bring temperatures 6 to 7 ºC higher than normal for this time of year throughout Spain. According to AEMET, 29 May to 1 June could be the warmest days for this time of year since at least 1950.

According to the results of a phase 2 trial, an oral norovirus vaccine generated a strong mucosal immune response and even reduced viral shedding in vaccinated volunteers. Signs of the vaccine's efficacy support its potential to address the lack of safe and reliable vaccines against this virus, which is a major cause of gastrointestinal infections worldwide. The results were published today in the journal Science Translational Medicine.

If immunisation rates continue to decline over an extended period, measles and even other eradicated diseases—such as rubella and polio—could re-emerge in the United States at endemic levels, according to a new study published today in the journal JAMA.

A set of articles published in Nature and Nature Methods draws a high-resolution map of the structure of and connections between the brain cells of mice. The map is based on data from a single cubic millimetre of brain and includes more than 200,000 cells, around 84,000 neurons and 524 million synaptic connections. Although this is a very small part of the mouse brain, it will help us understand how different types of cells work together.

A team from Canada and the United States has found a candidate to form part of a new class of antibiotics, lariocidin. This could be effective against multi-resistant bacteria. The finding is published in the journal Nature.