Barcelona Supercomputing Center (BSC)

An opinion piece signed by researchers from the Universities of Aberdeen and Nottingham (UK) has outlined some of the inaccuracies, exaggerations and misconceptions they say are taking place around research on the human microbiome. Some of these are curiosities, like the false belief that we have ten bacteria for every human cell. Others are more relevant, such as the fact that many specific associations between the microbiome and disease have not been confirmed in follow-up studies. According to the authors, it is important to raise awareness about myths and misconceptions to avoid unproductive research projects and preserve public confidence in microbiome science. The article is published in the journal Nature Microbiology.

An attribution study by World Weather Attribution (WWA) concludes that the heatwaves in Europe and North America this July would have been "almost impossible" without climate change. Over the past few weeks, southern Europe, parts of the United States, Mexico and China have experienced severe heatwaves with temperatures exceeding 45 °C. The WWA report notes that in China the heatwave was at least 50 times more likely due to the climate crisis.

Climate change made the late April episode of record temperatures in the Iberian Peninsula, Morocco and Algeria 100 times more likely to occur, with temperatures up to 3.5°C higher than they would have been without the climate crisis. This is one of the conclusions of an attribution study conducted by World Weather Attribution.

Faecal microbiota transplantation can be administered by oral capsules, colonoscopy or rectal enema, among other routes. Two meta-analyses evaluate its benefits and side effects for treating two types of disease. The first focuses on recurrent infections with Clostridioides difficile, a bacterium that can cause very severe diarrhoea; it includes six studies in Europe and North America involving 320 adults and concludes that in immunocompetent people, faecal transplantation is more effective than antibiotics. The second focuses on irritable bowel diseases, such as ulcerative colitis and Crohn's disease; it includes 12 studies with 550 participants and has less clear results.

Almost a decade after the previous edition, the Intergovernmental Panel on Climate Change (IPCC) has presented the synthesis report of its sixth assessment cycle (AR6) on Monday in Switzerland. "This synthesis report underlines the urgency of taking more ambitious action and demonstrates that, if we act now, we can still secure a sustainable and liveable future for all," said IPCC chair Hoesung Lee. 

The document includes the main findings of the three Working Group reports of 2021 and 2022 (Physical basis, Impacts, adaptation and vulnerability and Mitigation of climate change) and the three special reports of 2018 and 2019 (Global warming of 1.5°C, Climate change and land, Ocean and cryosphere in a changing climate). With this document, which is primarily addressed to policy makers, the IPCC closes its sixth assessment cycle.

Meta has applied language modelling to predict the structure of a large collection of proteins. The model, called ESMFold, is being presented this week in the journal Science after being published on the bioRxiv preprint article server in December 2022. EMSFold is faster than similar models such as AlphaFold, developed by Google's DeepMind and EMBL's European Bioinformatics Institute. The sequences of more than 617 million proteins - of which more than a third are predicted with a high degree of confidence - are published in open access in the ESM Metagenomic Atlas.

A study published in the journal PLOS Digital Health has analysed ChatGPT's performance on the US Medical Licensing Exams (USMLE). The results indicate that it could pass or come close to passing the exam.   

Two studies have found changes in the microbiome of patients affected by chronic fatigue syndrome. In particular, they have found a decrease in both butyrate and certain bacteria that produce butyrate. Butyrate is a factor related to the protection of the intestinal barrier and appears to play a role in the regulation of the immune system. Both papers are published in the journal Cell Host and Microbe.

An international team including researchers from Spain has analysed the level of exchange of microbial strains between different generations (vertical transmission) and between people who share a household or are close contacts (horizontal transmission). The analysis, published in the journal Nature, is based on about 9,700 microbiome samples from the faeces and saliva of people with different lifestyles from countries. According to the research, the transmission of bacteria is more frequent for the mouth microbiome than for the gut microbiome among people living together.   

Artificial intelligence algorithms using ChatGPT - the OpenAI company's GPT-3 language model - can identify speech features to predict the early stages of Alzheimer's disease with 80 per cent accuracy. The neurodegenerative disease causes a loss of the ability to express oneself that the algorithms could recognise, according to the journal PLOS Digital Health.