neurology

A team from Canada analyzed nearly one million emergency room visits for migraines or headaches that occurred between 2010 and 2023 in two Canadian provinces during the peak wildfire season. Their analysis shows that the presence of small particles less than 2.5 microns in diameter (PM2.5) from wildfire smoke was associated with an increase in emergency room visits for migraines and headaches. The study is published in JAMA Network Open. In Spain, the Ministry of Health has published health recommendations for action in the event of wildfires. The Community of Madrid, with several active fire fronts, has shared this video with safety and protection tips.

A new study reveals that the proportion of adults with dementia has risen significantly in Mexico, Peru and Puerto Rico over the last two decades, rising from one in ten older adults to almost one in six; a trend that runs counter to that seen in the US and other wealthy countries. Rates remained stable in Cuba and the Dominican Republic. The authors urge investment in prevention, dementia screening and care infrastructure. The study is published in JAMA Neurology.

Exposure to neurotoxic metals poses the greatest risk to children’s brain development between the ages of six and nine months, according to an analysis of baby teeth from 489 children in Mexico. The study, published in Science Advances, identifies this window as a critical developmental stage during which exposure to these metals is linked to increased behavioural problems in childhood and smaller brain volume. The study includes boys and girls aged between 8 and 14 years old and uses their milk teeth as biomarkers to reconstruct concentrations of lead, zinc, copper, manganese, magnesium, lithium, strontium, barium and tin, from 20 weeks before birth to 40 weeks after.

Spina bifida is a congenital malformation in which the spinal column does not close completely. A team in California (USA) has completed a phase 1 clinical trial testing, for the first time, a stem cell treatment combined with standard foetal surgery. The trial was conducted on six pregnant women with foetuses diagnosed with myelomeningocele, the most severe form of spina bifida. The six babies, born between 2021 and 2022, maintained the repair intact and had no serious adverse effects. The team will follow up carefully to ensure that the treatment remains safe and improves the children's quality of life. The results are published in The Lancet.

A study published in Nature suggests that a brain network that controls the execution of actions (SCAN), which was described in 2023, plays an important role in Parkinson's disease. Focusing treatments—such as transcranial stimulation—on the SCAN rather than other brain regions associated with movement could improve their effectiveness, according to the research.

People who ate more than 50 grams of high-fat cheese—such as cheddar, brie, or gouda—per day in the 1990s had a lower risk of dementia 25 years later than those who consumed less cheese, according to a study published in Neurology. The study is based on data from more than 27,000 people in Sweden with an average age of 58. The research also shows that those who consumed high-fat cream daily had a lower risk of dementia compared to those who did not consume it.

A research team identified five major phases of brain topology throughout human life—changes in the structure of neural connections—as detailed in an article published in Nature Communications. Using brain images from 3,802 people between the ages of 0 and 90, it defines four turning points around the ages of 9, 32, 66, and 83.

Periodontal disease—chronic inflammation of the gums—is correlated with minor brain damage in older people, according to a study published in Neurology Open Access. The study compared magnetic resonance images of the brains of 800 adults with periodontal disease with those of 343 people without the condition.

Researchers at Harvard Medical School have published new findings in Nature on the role of reduced lithium levels in Alzheimer's disease, based on experiments with mice and analysis of brain tissue and blood samples from humans. The team claims to have achieved improvements in memory in mouse models with lithium orotate. They caution that they have not proven that lithium is safe or effective in protecting against neurodegeneration in patients, and that their findings must be confirmed in humans through clinical trials.

Researchers in the United States have used stem cells created from patients with a very rare type of ALS, more prevalent in Brazil, to target a key gene in the stress response and reverse the damage suffered by motor neurons in the laboratory. They believe it is "a promising proof-of-concept for future therapeutic strategies" and "could help lay the foundation for genetically informed clinical trials".