A study in mice found that a molecule called TDI-11861 works as an oral male contraceptive, temporarily blocking sperm function. The paper, published in Nature Communications, presents the research as a step towards an on-demand male contraceptive drug: the user could take a birth control pill before sex and become fertile again the next day. Four co-authors of the study have founded a company in the US to develop such products. 

Research analysing data from more than 100,000 people in the UK followed for nearly a decade concludes that a higher intake of free sugars - added sugars or those naturally present in honey and fruit juice - is associated with an increased risk of cardiovascular disease. The study is published in BMC Medicine.

A study published in the journal PLOS Digital Health has analysed ChatGPT's performance on the US Medical Licensing Exams (USMLE). The results indicate that it could pass or come close to passing the exam.   

A study in California has found that 41% of deaths in the first year of life are due to genetic diseases. This percentage is higher than previously thought. According to the authors, strategies to improve neonatal genetic diagnosis may reduce infant mortality, as this diagnosis is sometimes missed or arrives late. The research is published in JAMA Network Open.

A phase 2 clinical trial has tested a type of immunotherapy based on oncolytic viruses in combination with chemotherapy for the treatment of triple-negative breast tumours. The results are published in the journal Nature Medicine.

Two studies have found changes in the microbiome of patients affected by chronic fatigue syndrome. In particular, they have found a decrease in both butyrate and certain bacteria that produce butyrate. Butyrate is a factor related to the protection of the intestinal barrier and appears to play a role in the regulation of the immune system. Both papers are published in the journal Cell Host and Microbe.

People who have a parent, sibling, or step-sibling with major depression have a higher risk of major depression themselves, according to research based on data from 2.9 million people in Denmark. This risk increases with the number of affected relatives and when exposure to depression occurs in childhood and adolescence, but does not vary by sex or kinship, says the study published in JAMA Psychiatry.

A series on breastfeeding published today in The Lancet highlights the economic and political power of formula companies, examines their marketing practices and the impact this has on the health of mothers and children.

As rising temperatures melt glaciers, meltwater can accumulate and form lakes nearby. These bodies of water represent a natural hazard because of the floods they cause if they overflow. Researchers have estimated that 15 million people are at risk from these floods, and more than half of them live in just four countries: India, Pakistan, Peru and China. The research is published in Nature Communications.

Early this morning, an earthquake with a magnitude of 7.8 struck southeastern Turkey and northern Syria. The authorities have reported thousands of deaths and extensive material damage. A second earthquake has occurred further north than the previous one.