CSIC Delegation in Andalusia and Extremadura

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by progressive loss of motor neurons. An international team has discovered evidence that ALS may have an autoimmune component, meaning that the immune system mistakenly attacks healthy cells, a hypothesis that had been considered by the scientific community. The study shows that inflammatory immune cells—called CD4+ T cells—attack certain proteins that are part of the nervous system in people with ALS. ‘These findings highlight the potential of therapeutic strategies aimed at improving regulatory T cells,’ the authors note in the research, published in Nature.

A team from Stanford University (USA) has analysed the conservation status of 1,376 species of scavenger animals. The results, published in the journal PNAS, indicate that 36% of them are threatened or in decline, especially large species and obligate scavengers, which depend exclusively on carrion for food. In contrast, the number of small and facultative scavengers, such as rodents, for which carrion is not their only source of food, is increasing. According to the authors, this ‘could increase the risks of diseases that large scavengers have helped to mitigate’.

A team from the Children's Hospital of Philadelphia and Penn Medicine (United States) has successfully treated a baby diagnosed with a rare genetic disorder using personalised CRISPR gene editing therapy. The baby, known only by the initials KJ, was born with a rare metabolic disease known as severe carbamoyl phosphate synthetase 1 (CPS1) deficiency. After spending the first months of his life in hospital on a very restrictive diet, KJ received the first dose of his tailored therapy in February 2025, between six and seven months of age. The treatment, which is being used for the first time for this type of disorder, was administered safely, and the baby is now growing well and improving. The case is detailed in a study published by The New England Journal of Medicine (NEJM).

A team from the Centre for Genomic Regulation (CRG) and Pompeu Fabra University (UPF) in Barcelona has developed an artificial intelligence tool capable of designing regulatory sequences for genes that do not exist in nature. When introduced into cells, these enhancers can increase or decrease gene activity in a specific way depending on the type of cell targeted. According to the authors, ‘the potential applications are enormous. It's like writing software, but for biology.’ The results are published in the journal Cell.

One study suggests that conservation efforts are concentrated around a small number of charismatic species, such as elephants. However, there are undervalued species, such as fungi, plants and invertebrates, that are critical to the functioning of ecosystems. The research, published in the journal PNAS, analysed more than 14,000 conservation projects spanning a 25-year period - from 1992 to 2016. Of the nearly $2 billion allocated by the projects, 83% went to vertebrates. Plants and invertebrates each received 6.6% of the funding, while fungi and algae received less than 0.2%.

An international team of researchers has reconstructed the first European seed dispersal network based on a literature review. The data indicate that extinction threats and demographic changes in the animals that disperse them have resulted in 30% of plant species having their dispersers listed as 'high concern.' The lack of seed dispersal could hinder the recovery of declining plant populations. The authors publish their results in the journal Science. 

With summer, the presence of these gelatinous creatures on the Spanish coasts bothers swimmers, who can suffer injuries if they come in contact with them. Are there more jellyfish than before? Which ones are the most dangerous? What should I do if one stings me? How can I avoid it? In this guide, we answer the main questions on jellyfish so you know how to act. 

The risks of ultraviolet radiation are well-known: it can cause everything from burns and spots to immune system alterations, cataracts, infections, and skin cancer. We need to protect ourselves from the sun, but do we really know how to do it? What is myth and what is reality? We answer the main questions when it comes to using sunscreens. 

In a paper published in Molecular Cell, a team of researchers led by the Spanish National Cancer Research Centre (CNIO) provides the first evidence that a possible cause of the hereditary type of ALS - familial ALS - is the accumulation in motor neurons of 'junk proteins', proteins with no function that accumulate unduly and prevent the cell from functioning properly. In addition, the research describes a new causal factor in the ageing process: nucleolar stress, which encompasses alterations in organelles called nucleoli. 

The European Medicines Agency (EMA) has recommended granting marketing authorisation in the European Union for a new therapy for the treatment of adult patients with amyotrophic lateral sclerosis (ALS), a rare and frequently fatal disease that causes muscle weakness and leads to paralysis. Qalsody (tofersen) is indicated for the treatment of adults with ALS who have a mutation in the SOD1 gene. There is currently only one treatment for ALS authorised in the EU (riluzole).