ageing

During pregnancy, women’s biological age accelerates, and this is partially reversed after childbirth. A review published in the journal Trends in Endocrinology & Metabolism suggests that closely spaced pregnancies may prevent the body from recovering fully and could lead to the accumulation of changes associated with biological ageing, with potential long-term consequences for maternal health. Although further studies are still needed to test this hypothesis, the authors suggest that the time elapsed between pregnancies could be a significant factor in women’s ageing.

Although menopause is a part of the lives of millions of women—accounting for about one-third of their lives in total—it remains one of the least-studied stages of women’s health. With up to 72 associated symptoms, there are still many unanswered questions about many of them and the impact of treatments. We spoke with experts to find out which questions remain unanswered.

Numerous sources, including the new dietary guidelines from the United States, recommend increasing protein intake. Now, a review of more than 350 studies —primarily in laboratory animals— carried out by two researchers suggests, on the contrary, that consuming less protein could have greater health benefits. According to the authors, “it is clear that protein provides benefits for muscle growth and the response to exercise in active people, but, given that most people are relatively sedentary, it is likely that many consume more protein than they actually need, which is likely to have negative health consequences”. The study is published in Cell Press Blue, a journal of the Cell group.

Ageing is characterised by the accumulation of cellular damage. Among the biomarkers associated with this process are epigenetic ‘clocks’, which analyse non-genetic modifications of DNA over time. However, these approaches have certain limitations, as they do not reflect the activity of specific genes. Now, a study published in Nature has analysed more than 11,000 transcriptomes from over 25 tissues in mice, rats, macaques and humans, showing that ageing-associated changes are conserved across species and cell types. The findings reveal universal transcriptomic signatures of ageing and mortality in mammals. Using these data, the authors developed their own molecular ‘clocks’, capable of estimating biological age and expected mortality.

A clinical trial (COSMOS) involving 958 healthy adults with an average age of 70 tested the ability of a multivitamin supplement, together with cocoa extract, to slow ageing. The results, published in Nature Medicine, show that the supplement slightly slowed two of the five biological markers of ageing measured after two years of daily use. The two markers affected were PCPhenoAge and PCGrimAge, whose rate of increase was reduced by 2.6 months and 1.4 months respectively. The slowing effect was greater among participants who initially showed more accelerated ageing. Cocoa showed no effect.

Genetics accounts for approximately 55% of the variability of human lifespan, which is more than double previous estimates, according to research published in the journal Science. The analysis is based on mathematical models and data from twin registries in Denmark, Sweden, and the United States. According to the authors, this high heritability is similar to that of most other complex human traits and to the influence of genetics on the life expectancy of other species.

An international team has analysed data from more than 700 mammal populations in zoos since 1970 and concludes that there has been an ageing of the animals and a decline in females of reproductive age. According to the authors, this jeopardises the role of zoos in conserving endangered wildlife species and promoting global biodiversity. The findings are published in the journal PNAS.

Consuming up to four cups of coffee a day is associated with an increase in telomere length in people with severe mental disorders, such as schizophrenia or bipolar disorder. Telomere length is an indicator of cellular ageing and is shorter in people with these disorders, although the causes are not clearly understood. According to the study, published in BMJ Mental Health, the effect shown is comparable to ‘a biological age five years younger’ in coffee drinkers. 

An international team, including Spanish researchers, has analyzed data from more than 86,000 people aged 51 to 90 from 27 European countries and concluded that multilingualism—the habit of speaking more than one language—is associated with a reduced risk of accelerated aging. According to the authors, who published their findings in the journal Nature Aging, “these findings could inform educational and public health policies aimed at promoting cognitive resilience and functional capacity in older populations.”