[The BMJ published an "expression of concern" about this study on November 12] A phase 3 clinical trial has analyzed the effectiveness of administering stem cells to prevent heart failure in people who have suffered a major heart attack. The trial included 396 patients, 136 of whom received a stem cell infusion. According to the results, published in The BMJ, the treatment significantly reduced the rates of heart failure, although it did not affect mortality.

Around 5,800 deaths per year in Spain between 2012 and 2021 can be attributed to heat—twice as many as during the 1990s—according to a report published in The Lancet. In addition, of the deaths that occurred during 2022, around 22,000 can be attributed to air pollution, the publication adds. The Countdown report describes the impact of climate change on global health with more than 50 indicators reviewed by scientists. In the period 2020-2024, 61% of Spanish territory experienced at least one month of extreme drought per year; this figure is six times higher than the average for the period 1951-1960.

Even if they have not been diagnosed with coeliac disease or wheat allergy, one in 10 people say they experience symptoms – gastrointestinal, fatigue or headache – after eating wheat or other foods containing gluten, according to a meta-analysis published in the journal Gut. This sensitivity is strongly associated with being female, psychological distress and irritable bowel syndrome, according to the study.

An Italian team has studied the factors that are increasing the frequency of massive floods in the Mediterranean region. According to their analysis, and in a context of climate change, a “dead end” effect is occurring in which mountains close to the sea block moisture and “trap” rain over the region. The article focuses on the floods suffered by the Emilia-Romagna region (Italy), but according to the authors, other Mediterranean areas with a similar geography, including Valencia and Catalonia, “could face the same risks and these events could become more frequent as the climate continues to change.” The results are published in Scientific Reports.  

Although it is accepted that the impact of a large meteorite was what caused the extinction of the non-avian dinosaurs at the end of the Cretaceous, there are various theories as to whether their disappearance was sudden or if their population was already in gradual decline. An international team with Spanish participation has analyzed new fossil data from northern New Mexico (USA) and concluded that they were not in decline, but were abruptly exterminated by the impact that occurred some 66 million years ago. The results are published in the journal Science.  

A team has analysed estimated data on exposure to pollution during and after pregnancy and its possible link to a diagnosis of autism in more than two million births in Canada between 2002 and 2022. Their findings are that greater exposure to small PM_2.5 particles containing sulphate or ammonium is associated with a higher likelihood of receiving a diagnosis of autism in the first five years of life. A slightly increased proportion was also observed with greater exposure to ozone during certain weeks of pregnancy and in the first year of life. The results are published in the journal JAMA Network Open.

Periodontal disease—chronic inflammation of the gums—is correlated with minor brain damage in older people, according to a study published in Neurology Open Access. The study compared magnetic resonance images of the brains of 800 adults with periodontal disease with those of 343 people without the condition.

An international team has used the CRISPR gene-editing tool to modify a key gene for the replication of the classical swine fever virus in pigs. The experiment, conducted on four animals, showed complete protection against the disease. According to the researchers, this breakthrough could serve as an additional method for controlling this type of virus, which entails significant economic and animal welfare costs. The results are published in the journal Trends in Biotechnology. 

Different antidepressant drugs cause different side effects in the body, in parameters such as heart rate, blood pressure or body weight, according to a meta-analysis published by The Lancet. For example, agomelatine administration is associated with weight loss, while other molecules such as maprotiline are associated with weight gain. The research brings together 151 studies and 17 reports from the US Food and Drug Administration (FDA), including more than 58,000 people and comparing 30 antidepressant drugs with a placebo.

Between 2003 and 2017, the incidence of six types of cancer—thyroid, breast, colorectal, kidney, endometrial, and leukaemia—increased in young adults in three-quarters of 42 countries included in a study published in Annals of Internal Medicine. For all of these types of cancer, except colorectal, diagnoses also increased in adults over the age of 50. The study analyses data on 13 types of cancer and notes that those with increasing incidence include some of the most obesity-related cancers, such as endometrial and kidney cancer.