University of La Rioja

One of the best-known genetic risk factors for developing Parkinson’s disease is carrying variants of the GBA1 gene. A new study published in the journal Nature Medicine compared the microbiomes of 43 carriers of this gene who had not developed the disease with those of 271 Parkinson’s patients and 150 healthy individuals. The results showed, in addition to alterations in the microbiome in the patient group, that 25% of the microbiome of carriers of this gene exhibited alterations, representing an intermediate profile between the other two groups. The results were validated using independent cohorts from the United Kingdom, South Korea, and Turkey. According to the authors, “alterations in the gut microbiome can identify individuals with both genetic and non-genetic risk in the general population who may be progressing toward Parkinson’s disease.”
 

A research team identified five major phases of brain topology throughout human life—changes in the structure of neural connections—as detailed in an article published in Nature Communications. Using brain images from 3,802 people between the ages of 0 and 90, it defines four turning points around the ages of 9, 32, 66, and 83.

A research team describes in the journal Science how to create organic molecules whose geometry breaks the so-called Bredt's rule. According to this 1924 rule, double bonds between two carbon atoms cannot exist at certain positions in a molecule. Until now, this rule has limited the types of molecules that scientists can imagine and make.

The Nobel Prize in Chemistry 2022 has been awarded to Barry Sharpless and Morten Meldal for laying the foundations of click chemistry, which quickly and efficiently joins molecular building blocks; and to Carolyn Bertozzi, who pioneered bioorthogonal reactions, which use this technique inside living organisms without altering the chemistry of the cell.