Eduard Vieta
Director of the Institute of Neurosciences at Hospital Clínic, Professor of Psychiatry at the University of Barcelona and researcher at IDIBAPS and CIBERSAM
This is a highly relevant comparative synthesis. The study is very informative and useful for updating clinical practice guidelines. Although the profile of antidepressants in terms of cardiovascular safety and tolerability was already known, the article quantifies clinical impressions and provides a quantitative and qualitative ranking that has great practical application.
Among the limitations of the study, I would highlight two: that it was not possible to perform a differential analysis by gender, which would be very interesting, and that the data on rare adverse effects are unreliable. However, the study reinforces the safety of drugs used for depression and reports on their differences with regard to possible effects on the cardiovascular system and weight, which are very relevant.