It is a genuinely original work with an imaginative approach to ultimately understand the evolution of the CRISPR-Cas9 system over billions of years.  

Improving CRISPR-Cas technology requires a good understanding of how these systems work from a biochemical and structural point of view. Knowing how they have changed over the course of evolution will allow us to approach these improvements from a new point of view, with potential applications in biotechnology and biomedicine.  

The study lays a foundation on which we can now continue working and be able to use this knowledge in tangible biotechnological applications. In any case, these basic studies are fundamental for the advancement of more applied sciences.

 

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