Age-related inflammation does not occur in some non-industrialized populations, which calls into question its universality
Aging is associated with an increase in chronic inflammation, a phenomenon known as inflammaging that is related to different diseases and that was considered universal. Now, an international team has analyzed data on 19 inflammation-associated proteins in four different populations: two industrialized (from Italy and Singapore) and two non-industrialized (the Tsimane population of the Bolivian Amazon and the Orang Asli population of Malaysia). The results show that, at least according to this form of measurement, in the non-industrialized populations there is no increase in inflammation with age, which questions whether this is a biological imperative and indicates that it would depend on lifestyles and social and cultural factors. The paper is published in letter format in Nature Aging.