Charles Marshall

Physical inactivity is a risk factor for the onset of Alzheimer's disease. An international team has studied nearly 300 people with preclinical Alzheimer's—without symptoms but with an accumulation of tau and beta-amyloid proteins in the brain—for 14 years to find out whether physical exercise can also influence its progression. The results indicate that even very moderate activity—walking between 3,000 and 5,000 steps per day—was associated with slower deterioration, while the benefits—which appear to be related to lower tau protein deposits—were greater and tended to stabilise with activity involving between 5,000 and 7,500 steps. The results are published in the journal Nature Medicine.

According to a study published today by The BMJ, people with dementia who are treated with antipsychotics are at increased risk of serious adverse events such as stroke, blood clots, myocardial infarction, heart failure, fractures, pneumonia, and acute kidney injury, compared with those who do not take them, . These findings extend the harms previously associated with the use of these drugs on these patients. 

A Lancet Commission study in 2020 estimated that hearing loss is associated with 8% of dementia cases worldwide. Now, a paper has analysed data from more than 400,000 people collected at the UK Biobank. Their findings show that the risk of developing dementia is 42% higher in people with hearing problems, but this increased risk disappears in those who use hearing aids. According to the authors, whose work is published in The Lancet Public Health, the data "highlight the urgent need to introduce hearing aids early when someone starts to experience hearing problems".