Antonio J. Ruiz Alcaraz

The Karolinska Institute has awarded the Nobel Prize in Medicine or Physiology to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for describing how the immune system is regulated so as not to harm us. His groundbreaking discoveries on peripheral immune tolerance have spurred the development of new treatments for cancer and autoimmune diseases.

Aging is associated with an increase in chronic inflammation, a phenomenon known as inflammaging that is related to different diseases and that was considered universal. Now, an international team has analyzed data on 19 inflammation-associated proteins in four different populations: two industrialized (from Italy and Singapore) and two non-industrialized (the Tsimane population of the Bolivian Amazon and the Orang Asli population of Malaysia). The results show that, at least according to this form of measurement, in the non-industrialized populations there is no increase in inflammation with age, which questions whether this is a biological imperative and indicates that it would depend on lifestyles and social and cultural factors. The paper is published in letter format in Nature Aging. 

Inflammation is all the rage. In fact, anti-inflammatory diets that claim to fight it. This is attested to by best-selling books and influencers, ready to give us the latest tips on how to lose weight, or rather, how to reduce inflammation. But what's the truth in all this, and what does inflammation have to do with being overweight?