The use of the antidepressants escitalopram, paroxetine, and duloxetine is associated with greater weight gain than the use of sertraline, according to the results of an analysis comparing data from more than 183,000 adults treated with one of eight types of antidepressants. Among these, bupropion is associated with the least weight gain, concludes the study, which is published in Annals of Internal Medicine.

A new technique developed at the Institut de Bioenginyeria de Catalunya (IBEC) has succeeded in assessing the health of mouse oocytes and embryos in a non-invasive way, according to a study published in PNAS. The method generates 3D images to visualise the metabolism of oocytes and embryos obtained by in vitro fertilisation and makes it possible to select those that are most likely to implant and develop, say the authors.

A neuroprosthetic interface allows a bionic leg to respond to the nervous system of amputees to make walking faster and more natural, says a study published in Nature Medicine. The clinical trial involved 14 people with below-knee amputations: seven with a surgically attached bionic leg compared to seven without the interface.

The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has recommended granting marketing authorisation in the European Union for Eurneffy (epinephrine), the first nasally administered medicine for the emergency treatment of allergic reactions. Anaphylaxis is the most severe form of allergic reaction that can occur within minutes of exposure to an allergen and can be life-threatening. Until now, treatment with epinephrine (also known as adrenaline) to reduce the anaphylactic reaction is done by intramuscular injection. 

In a new study in mice published in Science, researchers present CHARM, an epigenetic editor that can be used to silence prion protein throughout the brain. The tool offers a path to effective first-line treatment for patients with fatal prion diseases, as well as other neurodegenerative diseases caused by the toxic accumulation of unwanted proteins. 

Two articles published in Nature describe a new genome editing technique that enables the insertion, inversion, or deletion of long DNA sequences at specific positions in the genome. This is a one-step approach that could offer a simpler method for genome editing in the future. The authors describe a technique to create reprogrammable recombinases—key enzymes in genetic recombination. These enzymes are guided by RNA, which acts as a bridge, directing the recombinase to target sites and facilitating predetermined editing.

People who take multivitamins daily do not have a lower risk of mortality than people who do not use these products, according to a meta-analysis published in JAMA Network Open. The study pooled data from more than 390,000 people, followed for about 20 years in three different cohorts in the United States.  

The frequency and magnitude of extreme wildfires appear to have doubled in the last 20 years. Moreover, the six most extreme years for these events have occurred since 2017, according to a paper published in Nature Ecology & Evolution in which the authors used satellite data from 2003 to 2023. 

Ketamine extended-release tablets are effective, safe and well tolerated in patients with depression resistant to other treatments, according to a phase 2 clinical trial. Compared to intranasal or intravenous use of ketamine, these oral tablets are easier to administer and would provide less dissociative intensity, lower risk of abuse and cardiovascular adverse effects, the authors write in Nature Medicine. 

About one in 5,000 people have a genetic variant in the SMIM1 gene that results in a particular type of blood type called Vel negative. An international team of researchers now describes the same variant as being associated with a predisposition to obesity, metabolic disturbances and lower resting energy expenditure. Women studied with the variant weigh, on average, 4.6 kg more, while in men the difference is about 2.4 kg. The results are published in the journal Med, published by the Cell group.