Reacción a "Reactions to the identification of an exercise-secreted molecule that suppresses appetite in mice"

It is a very interesting work that identifies a metabolite produced during physical exercise, a compound called Lac-Phe (from lactate and the amino acid phenylalanine) that can effectively reduce food intake and therefore obesity, in mice. 

It has also been found in humans after exercise (although its effect on obesity has not been studied in humans). However, more research is needed to understand the molecular mechanisms by which this metabolite acts, and why food intake is reduced when it is secreted. We know that it acts in the brain by reducing appetite, and that these must be different mechanisms to those of the well-known leptin [a hormone associated with satiety]. 

It is speculative that there may be people who do not want to exercise but would benefit from the intake-reducing effect of Lac-Phe. It should be remembered that the work does not analyse the side effects that may result from taking this compound, and especially the appropriate concentration to inject into humans without toxic effects. This is another important avenue of research that is also needed.  

Finally, it would be relevant to analyse the relationship between Lac-Phe secretion and inflammation, which is a process related to physical exercise and is in fact involved in muscle regeneration.