Reacción a "Reactions: two studies add circuitry to CAR-T cells to improve immunotherapy"

These are two major basic studies that have been partially postulated before, but now provide interesting preclinical data. 

They make it possible to propose a more powerful CAR-T strategy, but also other options. The paper by Hui-Shan Li proposes a generic system for defining circuits, and its use in CAR-T would be one of the possible applications. 

The study by Greg M. Allen is more specific, defining that with this NOTCH system it is possible to reconstitute synthetic T-cell circuits for an anti-tumour response.  

The option for use is clear, but ultimately the most complex step remains to be taken: demonstrating this activity in humans. Clinical trials are ultimately what will tell us whether or not proposals such as these are effective.