Manel Juan
Head of the Immunology Service
The study is very well designed and its scientific quality is unquestionable. It demonstrates something that has been suggested many times before (with less solid data), namely that personalised vaccination with tumour antigen mRNA is effective in inducing a response and can, at the very least, increase survival times. This work confirms that it can generate responses with clearly very low adverse effects against one of the most lethal tumours, pancreatic ductal adenocarcinoma.
The work fits in perfectly with the growing number of studies showing evidence of these treatments. The main contribution is that it achieves this in a tumour generally considered not very reactive to immunotherapy and reconfirms those of us who consider that immunotherapy is a general approach more dependent on the immune status of the individual than on the type of tumour.
The most important limitation is that the sample size (of treated patients) is clearly very small and with a single-branch, non-randomised design. In any case, once the safety of the proposal has been confirmed, it seems that the next step to study is to see if simply advancing this "vaccination" before giving the checkpoint inhibitor [the other type of immunotherapy used] may be more reasonable and may allow better clinical results than vaccinating after administering the antibody as has been the case (surely as an ethical criterion of first giving the treatment that has demonstrated a certain functionality, although physiopathogenically it makes less sense). In any case, it is an important contribution to the field, although we cannot consider it to be disruptive or definitive.