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In mice, a therapy based on editing regulatory T-cells can suppress an immune reaction against gluten, according to a study in Science Translational Medicine. Studies in animals with coeliac disease would be needed to assess the efficacy of this cell therapy in restoring gluten tolerance, the authors say.
Around half of the 100 most popular videos on TikTok about Attention Deficit Hyperactivity Disorder (ADHD) contain statements that diverge from the scientific literature of reference, according to a study published in PLOS ONE. In addition, the research shows that there are discrepancies between young people and mental health professionals about the educational value of the content about ADHD on this social network.
A CNIC research team has identified a population of skin neutrophils that reinforce the physical protection of the tissue against infection. These immune cells are known for their microbicidal role, and the study published in Nature reveals that they also produce an extracellular matrix that reinforces the physical barrier of the skin.
The budget cuts affecting scientific activity in countries such as the United States and the fragility of centralised systems make decentralised and collaborative models a necessity. Science, intrinsically global, requires structures that can withstand local pressures. In this situation, Europe has the opportunity - and the duty - to lead a new paradigm where data is free, secure and accessible.
Clear evidence of human-induced climate change reached new heights in 2024 and some of the consequences will be irreversible for hundreds or thousands of years, according to the World Meteorological Organisation's State of the Global Climate 2024 report. It also highlights the enormous economic and social impacts of extreme weather conditions.
Grass-fed beef is not less carbon intensive than industrial beef, even after correcting for soil sequestration enhancement by rangeland grazing, according to a study published today in the journal PNAS that analysed emissions and livestock data from the United States.
A team in the US has tested the efficacy of baloxavir, an antiviral already on the market for treating common flu, against avian influenza in mice. The results, published in the journal Nature Microbiology, show that it is more effective than the currently recommended oseltamivir (Tamiflu) except when the infection is via the mouth, in which case it is equally effective. According to the authors, baloxavir ‘could be considered for the potential treatment of serious H5N1 virus infections in humans’.
Until now, one hypothesis suggested that life on Earth could have arisen from lightning striking a body of water. However, a new study claims that the synthesis of molecules necessary for the emergence of life could have originated from ‘micro-lightning’ in water droplets. According to the study, published in Science Advances, the formation of organic compounds with carbon-nitrogen bonds from gas molecules could be a possible mechanism for creating the basic components of life on the early Earth.
Discovered years ago, PINK1 is a protein directly linked to Parkinson's disease, but it was not known what it looks like, how it binds to the surface of damaged mitochondria or how it is activated. A study published this week in Science has for the first time determined the structure of this protein. The authors suggest that this new information could help in finding new treatments.
23% of people infected with SARS-CoV-2 between 2021 and 2023 developed long covid and more than half of them had persistent symptoms for two years. These are the main conclusions of a study led by ISGlobal that followed more than 2,700 people in Catalonia. The results are published in the journal BMC Medicine.