Autor/es reacciones

Gonzalo Jiménez-Oses

Ikerbasque research professor at the Computational Chemistry Laboratory of CIC bioGUNE

Computational protein design is based on prediction algorithms for both the structures of proteins with known sequences and the amino acids that stabilize these structures. The implications of these methodologies in the fields of structural biology, biomedicine, and new materials are extraordinary. On one hand, it is exponentially accelerating the elucidation of the three-dimensional shape of receptors, molecular signaling molecules, transcription factors, enzymes, antibodies, and more; on the other hand, it has irreversibly opened up new areas of research dedicated to creating protein structures that do not exist in nature with 'custom-made' properties, such as biological drugs, vaccines, catalysts, and more.

The 2024 Nobel Prize in Chemistry awarded to Baker, Hassabis, and Jumper recognizes the enormous relevance and utility of computational tools for advancing knowledge in structural biology and their application in the generation of new therapies, materials, and bioreactors.
 

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