Reacción a "Reactions: method developed to produce protein-based drugs that can be administered orally"

This is a good study carried out by one of the world's leading laboratories in the development of cyclic peptides. The study is rigorously detailed, as indicated by its publication in one of the most important journals in the field of chemistry.

Peptides are very small proteins. There are many drugs based on peptides and proteins. However, peptides and proteins do not reach the blood orally because they are degraded during digestion. This paper describes a new method to develop cyclized peptides that can reach the blood orally and through intestinal absorption. There are many methods of peptide cyclization and combinatorial chemistry, but it appears that this strategy has identified peptides that reach the blood with high efficiency, up to 18% of the administered dose.  

For the time being, only one peptide has been developed with this platform against a therapeutic target for which alternatives already exist. To test whether this method will be truly transformative, it will be necessary to wait for the development of peptides against other targets of interest.