Francisco Carmona

Polycystic ovary syndrome (PCOS) has recently been renamed polyendocrine metabolic ovarian syndrome (PMOS), to emphasise its metabolic and endocrine dimensions, rather than viewing it solely as a gynaecological condition. A study involving more than 400,000 women has linked PPOS to an increased incidence of cardiovascular events, specifically atherosclerotic cardiovascular disease. This association was observed independently of traditional cardiovascular risk factors such as diabetes, dyslipidaemia, obesity, and hypertension, suggesting that these factors alone do not fully explain the relationship. The study included women aged 18–50 years with PMOS and drew data from the Optum Clinformatics Data Mart patient database. The findings were published in The Lancet Obstetrics, Gynaecology & Women’s Health.

A US study analysed data from more than 110,000 women since 1993 and found that those with a history of endometriosis had a 31% higher risk of premature death (before the age of 70). In absolute terms, the rate of premature death in women with and without endometriosis was 2 and 1.4 per 1,000 person-years, respectively. In contrast, the presence of uterine fibroids was not associated with an overall increased risk, although the risk of death from gynaecological tumours was increased. The results are published in The BMJ.