Reacción a "Reactions: two studies describe what may be the cells that sustain allergies over time"

The study is very complete, of good quality, with a lot of novel experimentation and a lot of bioinformatics. Above all, it is a study carried out on peripheral blood cells in children, with the difficulty that this entails due to the small number of samples that can be obtained from them. 

It provides interesting information on the markers and type of IgG+ memory B cells, which would be the cells prior to differentiation into IgE-producing plasma cells highly specific to peanut protein.  

The article shows that IgE-producing B cells are not generated directly, but that there has been a class switch from IgM to IgG, prior to becoming IgE+ B cells.  

This study confirms in children what had previously been seen in adults, for example in two articles from 2016 and 2020, one with peripheral blood and the other with mucosal cells. It is therefore not entirely novel, but it does confirm what has been observed by other authors.  

The only major limitation of the study is that, because they did not have enough sample, they sometimes had to pool cells from several individuals.