Reacción a "A review confirms major differences in the cardiometabolic side effects of 30 antidepressants"

This is a methodologically sound study with a large sample size and authors of great prestige and recognized experience in network meta-analysis and psychopharmacology. The quality of the data and statistical rigor allow for reliable and valid comparisons between different antidepressants, something unusual in previous literature, which has tended to focus on specific parameters or antidepressants. This study provides a comprehensive and up-to-date overview of the physiological effects of a wide range of antidepressants, particularly cardiometabolic parameters, which is an important innovation and an advance over previous studies that were more partial or focused on a single drug or parameter.

In clinical practice in our field in Spain, the results are of enormous relevance, as they allow for more personalized prescribing of antidepressants, taking into account the somatic pathologies and comorbidities of each patient, especially cardiovascular and metabolic ones, which are also one of the main concerns in terms of adverse effects in patients. This type of evidence facilitates shared decision-making between clinician and patient, allowing for a more accurate assessment of the risk-benefit balance of each treatment.