This meta-analysis [published by] The BMJ rigorously and comprehensively analyses the impact of different intermittent fasting strategies on body weight and cardiometabolic risk factors, comparing them with traditional calorie restriction [diets]. The authors do an excellent methodological job, combining direct and indirect data through a network of clinical trials, which allows more precise estimates to be extracted.
Particularly noteworthy is the clarity with which they state the limitations of the study (relatively short trial duration, high heterogeneity between strategies, low to moderate certainty of the evidence), which adds value and transparency to their conclusions. Although the weight loss benefits are modest, this study positions alternate-day fasting as a valid additional tool within a personalised dietary approach, without claiming to replace other strategies. In the clinic, it could be useful as long as it is tailored to the needs and characteristics of the patient.