Reacción a "Researchers discover how extrachromosomal DNA circles contribute to the aggressiveness of pancreatic cancer"

This is an important contribution to the field. The study demonstrates a potentially important role for ecDNA (extrachromosomal DNA) in pancreatic cancer. 

The paper, through its thoughtful integration of organoid models, genomic and cell biological studies, and use of clinical data, highlights how ecDNA drives intratumoral genetic heterogeneity in pancreatic cancer. The study sheds important light on how ecDNA, including when it carries the MYC oncogene, contributes to poor outcomes for patients with pancreatic cancers.