Ignacio Melero
Professor of Immunology at the University of Navarra, CIMA researcher and co-director of the Department of Immunology and Immunotherapy at the Clínica Universidad de Navarra.
It is a technical prodigy that uses multiple technologies to make it feasible (massive sequencing, bioinformatics, cell separation, gene transfer). The work demonstrates that it is feasible and that the treatment can be safely administered to 16 patients.
The clinical response (efficacy) in these patients is, for the moment, modest for reasons that will need to be clarified to improve clinical efficacy in future studies.
Another criticism is that the procedure has been tried in many patients without being possible in many of them. Technology and production time need to be significantly improved.