Reacción a "Reactions: use of benzodiazepines increases the risk of miscarriage"

This is a very large case-control study, but I think these results have a large risk of confounding by indication, i.e. patients with mental health problems receiving more benzodiazepines.

Benzodiazepine use is very broadly defined, and more stringent definitions lead to attenuated associations. Without a plausible mechanism, and pharmacological assumptions about short-acting vs. long-acting that are untenable, it seems to me that this study should not change current practice.

Of course, we should always be prudent during pregnancy with any medication use. However, anxiety and severe insomnia undoubtedly also have detrimental effects on the mother and unborn child.