Amelia Martí del Moral
PhD in Pharmacy, Professor of Human Physiology at the University of Navarra, member of the CIBER Physiopathology of Obesity, Carlos III Health Institute and IDISNA (Navarra)
This finding is in line with previous work from our [research] group published in 2019 in which we performed a systematic review aimed to evaluate the potential association of antidepressant and antipsychotic therapy with body weight gain in cohort studies. We included 27 independent eligible cohort studies with children (2-18 years old) and adult (18-103 years old) subjects. Most of the studies included showed a 5% weight gain in individuals using antidepressant therapy. However, Quetiapine, Haloperidol, Trifluoperazine, Risperidone, Aripiprazole, Olanzapine, and Clozapine increased body weight ≥7% from baseline, which is considered a clinically significant result. Interestingly, weight loss was found in individuals treated with Bupropion.